ABSTRACT
Intestinal malrotation is a congenital anomaly caused by incomplete rotation or absence of rotation of the primitive intestine along the axis of the upper mesenteric artery during embryonic development. Embryonic development and its anatomical variations were described by Dott in 1923. Intestinal malrotation is a rare condition among adults - prevalent in a mere 0.0001% to 0.19% of the population -, and it may be associated with other anatomical deformities. It can be asymptomatic or manifest with varying intensity, from obstruction to necrosis of intestinal segments. In general, this abnormality is diagnosed in the first year of life; however, symptomsmay appear later in life,making diagnosis in adults difficult on account of non-specific symptoms. In the present study, we report a case of intestinal malrotation associated with chronic non-specific symptoms progressing to mesenteric angina. (AU)
Subject(s)
Humans , Female , Aged , Torsion Abnormality/complications , Torsion Abnormality/diagnostic imaging , Mesenteric Artery, Superior , Internal Hernia , Meckel Diverticulum/diagnosisABSTRACT
OBJECTIVE: This study was developed to determine whether the generation of free radicals, induced by ischemia followed by reperfusion in a model of chronic intravesical obstruction in rats, would lead to damage in the detrusor. It also investigates the possible protective action of the flavonoid galangin on the tissue lesion induced by lipid peroxidation. MATERIALS AND METHODS: Twenty-one male rats were divided into three groups of seven animals each. Group A was subjected to a sham procedure; group B to partial obstruction of the bladder neck; and group C to partial obstruction of the bladder neck, but also received a diet rich in the flavonoid galangin. All the animals were subjected to urodynamic evaluation and then sacrificed. The bladders were sent for enzymatic tests. RESULTS: The urodynamic showed that group B developed significantly greater numbers of involuntary contractions of the detrusor, greater post-micturition residue and lower compliance. The group A presented TEAC levels greater than to the group B. Comparative analysis of group A, B and C demonstrated significantly greater malondialdehyde levels in group B in relation to groups A and C. The group B presented smaller contraction amplitudes than did groups A and C, in electrically stimulated contractions. CONCLUSIONS: That oxidative stress is implicated in the damage to the detrusor musculature following a period of chronic intravesical obstruction. We show, for the first time, that administration of an antioxidant prior to and following the start of chronic obstruction makes it possible to avoid the cellular lesions that cause detrusor dysfunction.
Subject(s)
Animals , Male , Rats , Antioxidants/therapeutic use , Oxidative Stress/physiology , Urinary Bladder Neck Obstruction/etiology , Urination Disorders/etiology , Antioxidants/pharmacology , Disease Models, Animal , Electrophysiological Phenomena , Flavonoids/administration & dosage , Muscle Contraction , Malondialdehyde/analysis , Mutagens/administration & dosage , Urodynamics , Urinary Bladder Neck Obstruction/physiopathology , Urinary Bladder/enzymologyABSTRACT
Os autores apresentam um caso de linfoma maligno de testículo. Fazem também uma revisäo de literatura e discutem o caso